|
KMID : 1038120190520050464
|
|
Clinical Endoscopy
2019 Volume.52 No. 5 p.464 ~ p.471
|
|
|
Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue
|
|
Jung Hee-Jae
Hong Su-Jin
Kim Shin-Hee
|
|
|
Abstract
|
|
|
Background/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.
Methods: Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.
Results: Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.
Conclusions: The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.
|
|
|
KEYWORD
|
|
|
Epithelial-mesenchymal transition, Immunohistochemistry, Early gastric cancer, Endoscopic submucosal dissection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|